UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan
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چکیده
منابع مشابه
CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.
BACKGROUND Both L-type amino acid transporter 1 (LAT1) and CD98 are strongly expressed in primary human cancer and play essential roles in tumor growth. We studied the clinicopathological significance of LAT1 and CD98 expression in hypopharyngeal squamous cell carcinoma (SCC). METHODS A total of 70 patients with stage III/IV disease were retrospectively reviewed. Immunohistochemical staining ...
متن کاملUGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan.
PURPOSE Irinotecan (CPT-11) is approved in metastatic colorectal cancer treatment and can cause severe toxicity. The main purpose of our study was to assess the role of different polymorphisms on the occurrence of hematologic toxicities and disease-free survival in high-risk stage III colon cancer patients receiving 5-fluorouracil (5FU) and CPT-11 adjuvant chemotherapy regimen in a prospective ...
متن کاملThe relationship between UGT1A1 gene polymorphism and irinotecan effect on extensive-stage small-cell lung cancer
AIMS To analyze the distribution of uridine diphosphate glucuronosyltransferase (UGT)1A1 gene polymorphisms in Chinese patients with extensive-stage small-cell lung cancer (E-SCLC), and to evaluate correlations between the UGT1A1 gene polymorphisms and toxicity, and efficacy of irinotecan (CPT-11) based regimen in the patients with E-SCLC. METHODS The study analyzed the distribution of UGT1A1...
متن کاملBilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis
Clear cell carcinoma of ovary is uncommon ovarian tumour that arises from surface epithelium of ovary. It has well-known association with ovarian endometriosis. We report here the first case of bilateral clear cell carcinoma of ovaries in a 40-year-old woman with a 17-year history of bilateral ovarian endometriosis. In addition, during the longstanding duration of the endometriosis, the patient...
متن کاملTwo cases of clear cell ovarian cancer in young patients
Background: Ovarian cancer is the most common cause of cancer death worldwide. Incidence of ovarian cancer is more common in postmenopausal women. Premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. Case Presentation: The patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was ...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 2016
ISSN: 0368-2811,1465-3621
DOI: 10.1093/jjco/hyw163